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São Paulo; s.n; 2003. [105] p. ilus, tab, graf.
Thesis in Portuguese | LILACS | ID: lil-415063

ABSTRACT

Estudados 120 ratos da raça Wistar, divididos em oito grupos de 15 animais. Os animais foram submetidos à injeção dos fármacos buflomedil, pentoxifilina e nicotina. No sétimo dia de pós-operatório, o retalho dorsal foi fotografado, sua imagem digitalizada e transferida para o computador. Com o programa de imagem (Image Tool), a foto foi delineada e subdividida em cinco diferentes áreas: total, isquêmica, de necrose, de viabilidade e preservada. A obtenção dos valores percentuais das cinco diferentes áreas do retalho dorsal levou a uma maior compreensão da ação do buflomedil e da pentoxifilina na microcirculação do retalho, principalmente na área isquêmica / The study was conducted on 120 male Wistar rats, arranged in 8 groups of 15 animals each. The animals underwent a injection schedule of the following drugs: buflomedil, pentoxifylline and nicotine. At the end of the seventh post-op day, the dorsal flap was photographed, its image was digitalized and entered into a computer. With an image software (Image Tool) the photo was delineated and subdivided into five different segments: total, ischemic, necrotic, viability and preserved segments. The obtaining of the percentage values of the five different segments of the dorsal flap, allowed a better understanding of the action of buflomedil and pentoxifylline upon the microcirculation of the flap...


Subject(s)
Humans , Male , Adult , Back/surgery , Microcirculation , Surgical Flaps/blood supply , Acetates/pharmacokinetics , Regional Blood Flow , Image Interpretation, Computer-Assisted , Nicotine/administration & dosage , Nicotine/adverse effects , Pentoxifylline/pharmacokinetics , Tissue Survival
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